Quantifoil Micro Tools GmbH was founded in Jena, Germany in 1999, specializing in the production and sale of proprietary QUANTIFOIL® support films for electron microscopy. Today, QUANTIFOIL® support films encompass 25 different geometric structures and are compatible with the full range of TEM grid materials and designs. The continuously expanding product portfolio includes: UltrAuFoil® perforated gold support films for high-throughput, high-resolution single-particle analysis; robust support films providing larger open viewing areas for focused ion beam milling and tomography; and finder grids for integrated methods such as correlative light and electron microscopy.
■ Product Portfolio
Vicbio Biotechnology Co., Ltd. provides full range of Quantifoil products.
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● HexAuFoil® ultra-small hole gold supports: This revolutionary new microperforated gold support film achieves zero-dose reconstruction through displacement-free imaging, significantly enhancing image quality and improving the efficiency of high-resolution structure determination in drug development and basic research.
● QUANTIFOIL® holey carbon film supports: QUANTIFOIL® transmission electron microscopy perforated amorphous carbon support films feature uniform pore size, shape, and spacing, making them an ideal choice for modern automated data acquisition. The carbon films are suitable for various applications including single-particle analysis, tomography, and correlative electron microscopy, and can be used with all types of grids, including finder grids and large-view grids.
● UltrAuFoil® holey gold supports: UltrAuFoil® ultra-stable gold support films reduce beam-induced motion, enabling better reconstruction with less data. They are an ideal choice for researchers seeking to improve the resolution and data quality in single-particle analysis, including high-throughput workflows required for structure-based drug discovery.
● Additional UltraThin Carbon Layer (UTC): The addition of an ultra-thin continuous carbon (UTC) layer improves particle distribution and quality. The carbon surface adsorbs biomolecules across the entire pore area, enhancing dispersion while isolating particles from the damaging air-water interface to preserve integrity.
● Conventional and Continuous Carbon-Coated Grids: Traditional amorphous carbon support films offer non-uniform pore sizes, shapes, and arrangements, making them suitable for a wide range of applications, including particles of varying sizes. Depending on experimental needs, continuous, perforated, or mesh-patterned carbon films can be selected.
● SiO2 Films: Featuring a highly functionalizable glass-like surface, these films are particularly suitable for cell culture. Their excellent mechanical strength withstands additional manual handling required for on-grid cell culture, tomography, correlative electron microscopy, and cryo-focused ion beam milling.
● QUANTIFOIL® Active self-wicking grids: Designed specifically for the Chameleon system, these self-blotting grids represent a novel grid technology that eliminates variability associated with using external filter paper for sample blotting.
■ Product List
| QUANTIFOIL Type | Hole Size in µm | Spacing in µm | Period in µm |
| R 0.6/1 | 0.6 | 1 | 1.6 |
| R 1/2 | 1 | 2 | 3 |
| R 1/4 | 1 | 4 | 5 |
| R 1.2/1.3 | 1.2 | 1.3 | 2.5 |
| R 1.2/20 | 1.2 | 20 | 21.2 |
| R 2/1 | 2 | 1 | 3 |
| R 2/2 | 2 | 2 | 4 |
| R 2/4 | 2 | 4 | 6 |
| R 3/3 | 3 | 3 | 6 |
| R 3/5 | 3 | 5 | 8 |
| R 3.5/1 | 3.5 | 1 | 4.5 |
| R 5/10 | 5 | 10 | 15 |
| R 5/20 | 5 | 20 | 25 |
| R 6/6.5 | 6 | 6.5 | 12.5 |
| R 6/100 | 6 | 100 | 106 |
| R 10/5 | 10 | 5 | 15 |
| R 10/10 | 10 | 10 | 20 |
| R 10/20 | 10 | 20 | 30 |
| R 17/5 | 17.5 | 5 | 22.5 |
