品名: FPS-ZM1

货号: N-1635-1

规格: 5mg

品牌：rPeptide

储存温度：-20℃

序列：N/A

来源：N/A

描述：A high-affinity RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivos1,[2]. In a rat model of intracerebral hemorrhage, FPS-ZM1 attenuates blood-brain barrier and white matter fiber damage[3]. It ameliorates inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling[4]. Attenuates AGE-induced neuroinflammation and oxidative stress in rat microglia[5]. BBB permeable.

分子量：327.1

纯度：>98%