AlphaThera | AT7004 | oYo-Link® DM4

品名：oYo-Link® DM4

货号：AT7004

规格：100 μg; Bulk

品牌：AlphaThera

产品描述

Site-specifically label your antibody with oYo-Link® DM4 drug for cell killing assays to prototype your ADC candidates.

oYo-Link® DM4 is an Antibody-Drug Conjugation reagent allowing for rapid, site-specific labeling of DM4 drug labels to the heavy-chains of compatible antibodies with up to two labels per antibody. oYo-Link® limits the attachment of the DM4 drugs to the heavy chains of the antibody and therefore ensures that the drug label does not interfere with antibody binding. Furthermore, site-specific labeling limits 1-2 DM4 drugs to be attached per antibody, providing precise antibody-drug conjugate ratios. As a synthetic derivative of the microtubule-targeted agent ravtansine, also known as the maytansinoid DM4, the DM4 ADC is an antibody-conjugatable, anti-mitotic agent that overcomes systemic toxicity associated with ravtansine and enhances tumor-specific delivery.

 Applications：Antibody conjugation reagent for Targeted cell death; Targeted cell death for cancer cells; High-throughput screening with cell killing assays.