AlphaThera | AT7002 | oYo-Link® DM1

品名：oYo-Link® DM1

货号：AT7002

规格：100 μg; Bulk

品牌：AlphaThera

产品描述

Site-specifically label your antibody with oYo-Link® DM1 drug for cell killing assays to prototype your ADC candidates.

oYo-Link® DM1 is an Antibody-Drug Conjugation reagent allowing for rapid, site-specific labeling of DM1 drug labels to the heavy-chains of compatible antibodies with up to two labels per antibody. oYo-Link® limits the attachment of the DM1 drugs to the heavy chains of the antibody and therefore ensures that the drug label does not interfere with antibody binding. Furthermore, site-specific labeling limits attachment of 1-2 DM1 drugs per antibody, providing precise antibody-drug conjugate ratios. Any free oYo-Link drug will not penetrate into cells, so there is no background cell killing, and there is no need for purification post conjugation so researchers can proceed directly to the cell killing assay. As a synthetic derivative of the microtubule-targeted agent mertansine, also known as the maytansinoid DM1, the DM1 ADC is an antibody-conjugatable, anti-mitotic agent that overcomes systemic toxicity associated with mertansine and enhances tumor-specific delivery.

 Applications：Antibody conjugation reagent for Targeted cell death; Targeted cell death for cancer cells; High-throughput screening with cell killing assays.